Mian Chen

Title: Mian Chen - Innovator in Peptide Agonist Discovery

Introduction

Mian Chen is a notable inventor based in San Francisco, CA. He has made significant contributions to the field of peptide ligand discovery. His innovative work focuses on methods for discovering agonists for membrane-bound receptors.

Latest Patents

Mian Chen holds a patent titled "Method for discovery of peptide agonists." This invention relates to peptide ligand discovery and is particularly directed to a method for the discovery of agonists for membrane-bound receptors. The inventive detection system involves the use of a 'tethered' ligand for probing receptor binding. The general detection system includes a membrane, a membrane-bound receptor, and a chimeric ligand presenting molecule. This chimeric protein forms the tethered ligand and in turn includes a membrane domain, a linker domain, a ligand domain, and a cleavable terminal domain. The 'ligands' of the system are exposed by the addition of a specific peptidase that cleaves at the designated sequence. The sequence of the ligand that produces a signal as a result of the interaction between the agonist and receptor can then be isolated using sib selection. Mian Chen has 1 patent to his name.

Career Highlights

Mian Chen is affiliated with the University of California, where he continues to advance research in his field. His work has implications for various applications in biochemistry and pharmacology.

Collaborations

Mian Chen has collaborated with notable colleagues, including Maki Ishii and Harold S. Bernstein. Their combined expertise contributes to the innovative research environment at the University of California.

Conclusion

Mian Chen's contributions to peptide agonist discovery highlight his role as an influential inventor in the scientific community. His innovative methods pave the way for advancements in receptor research and therapeutic applications.