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Years Active: 2018-2023
Title: Mehmet Inan: A Pioneer in Synthetic Promoter Design
Introduction
Mehmet Inan is an innovative inventor based in Antalya, Turkey. He is known for his significant contributions to the field of synthetic biology, particularly through his groundbreaking work on the alcohol dehydrogenase 3 (ADH3) promoter. With a total of three patents to his name, Inan's research holds promise for advancements in recombinant protein production.
Latest Patents
His latest patents focus on the determination of regulatory DNA regions of the ADH3 promoter and the design of synthetic promoters for recombinant protein production. This invention includes polynucleotide sequences, vectors, and expression cassettes featuring DNA regions that regulate the ADH3 promoter. Furthermore, it entails host cells that incorporate these vectors and expression cassettes, leading to the production of recombinant proteins. Inan conducted deletion analyses in the ADH3 promoter to identify regions that influence promoter strength, achieving notable findings. For instance, the deletion of nucleotides between 539 and 638 resulted in a remarkable 63% increase in ADH3 promoter activity. By utilizing positive regulatory regions identified, Inan created five different synthetic promoters that achieved promoter activities ranging from approximately 165% to 200%. Additionally, his methods offer a multi-copy strategy for the high-titer and high-purity production of multi-subunit proteins, such as antibodies, in transformed microbes.
Career Highlights
Throughout his career, Mehmet Inan has worked with notable companies like H. Lundbeck A/S and Alderbio Holdings LLC, where he has contributed his expertise in synthetic biology and protein production processes.
Collaborations
Inan has collaborated with professionals such as Danielle Mitchell and Leon F Garcia-Martinez, further enhancing his research through teamwork and collective knowledge. These collaborations have led to significant advancements in the understanding and application of synthetic promoters.
Conclusion
Mehmet Inan’s innovative patents and contributions to synthetic biology illustrate his dedication to advancing the field of recombinant protein production. His work has the potential to revolutionize the way complex proteins are produced, leading to improvements in various biotechnological applications. As an inventor, he continues to shape the future of synthetic biology with his advancements and collaborations.