Mehmet Fatih Bolukbasi

Title: Innovations by Mehmet Fatih Bolukbasi

Introduction

Mehmet Fatih Bolukbasi is an accomplished inventor based in Worcester, MA (US). He has made significant contributions to the field of genetic engineering, particularly in the area of hemoglobinopathies. With a total of 4 patents to his name, Bolukbasi is recognized for his innovative approaches to gene editing and therapeutic methods.

Latest Patents

One of his latest patents is titled "Targeting BCL11A distal regulatory elements with a CAS9-CAS9 fusion for fetal hemoglobin reinduction." This invention provides methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. It also includes methods for treating hemoglobinopathies through the reinduction of fetal hemoglobin levels. Another notable patent is related to "CAS9-CAS9 fusion proteins." This invention offers a Cas9 platform that enhances single-site nuclease gene editing precision within the human genome. The Cas9 nuclease/DNA-targeting unit (Cas9-DTU) fusion protein precisely delivers a Cas9/sgRNA complex to specific target sites, improving target site binding precision and nuclease activity.

Career Highlights

Bolukbasi has worked with prestigious institutions such as the University of Massachusetts and Children's Medical Center Corporation. His work has focused on advancing genetic research and developing innovative solutions for medical challenges.

Collaborations

Some of his notable coworkers include Scot Andrew Wolfe and Ankit Gupta. Their collaborative efforts have contributed to the success of his research and inventions.

Conclusion

Mehmet Fatih Bolukbasi is a prominent inventor whose work in genetic engineering has the potential to transform treatments for hemoglobinopathies. His innovative patents and collaborations highlight his commitment to advancing medical science.