The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2024
Filed:
Jul. 20, 2018
Targeting bcl11a distal regulatory elements with a cas9-cas9 fusion for fetal hemoglobin reinduction
The Children's Medical Center Corporation, Boston, MA (US);
University of Massachusetts, Boston, MA (US);
Daniel E. Bauer, Cambridge, MA (US);
Scot Wolfe, Boston, MA (US);
Mehmet Fatih Bolukbasi, Brighton, MA (US);
Benjamin Roscoe, Worcester, MA (US);
Pengpeng Liu, Worcester, MA (US);
Kevin Luk, Worcester, MA (US);
Yuxuan Wu, Boston, MA (US);
Jing Zeng, Boston, MA (US);
THE CHILDREN'S MEDICAL CENTER CORPORATION, Boston, MA (US);
UNIVERSITY OF MASSACHUSETTS, Boston, MA (US);
Abstract
Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.