Location History:
- Rancho Palos Verde, CA (US) (2009)
- Nyon, CH (2010)
- Meyrin, CH (2011)
Company Filing History:
Years Active: 2009-2011
Title: Matteo Villain: Innovator in Chemical Peptide Ligation
Introduction
Matteo Villain is a prominent inventor based in Meyrin, Switzerland. He has made significant contributions to the field of chemical peptide ligation, holding a total of 4 patents. His innovative methods have advanced the efficiency of synthesizing polypeptides and proteins.
Latest Patents
One of his latest patents is titled "Chemical peptide ligation with three or more components." This invention provides a method for assembling oligopeptide intermediates in a native chemical ligation reaction. It effectively eliminates self-ligation of bi-functional intermediates by utilizing a bi-functional intermediate with an N-terminal heterocyclic protecting group. This advancement is particularly useful in methods for convergent synthesis of polypeptides and proteins.
Another notable patent is "Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation." This invention outlines a method for synthesizing oligopeptides or polypeptides through the convergent assembly of multiple pairs of oligopeptides in chemical ligation reactions. The key aspect of this invention is an oligopeptide with a C-terminal disulfide-protected carboxythioester group, which can be deprotected to generate a free C-terminal thioester moiety. This allows for a single precursor to engage in successive chemical ligation reactions, enhancing the efficiency of native chemical ligation.
Career Highlights
Matteo Villain is currently employed at Amylin Pharmaceuticals, Inc., where he continues to innovate in the field of chemical synthesis. His work has been instrumental in improving the methodologies used for the assembly of complex peptide structures.
Collaborations
Throughout his career, Matteo has collaborated with notable colleagues such as Hubert Gaertner and Paolo Botti. These collaborations have further enriched his research and development efforts in peptide chemistry.
Conclusion
Matteo Villain's contributions to chemical peptide ligation have significantly impacted the field of protein synthesis. His innovative patents and collaborative efforts continue to pave the way for advancements in biochemistry and molecular biology.
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