The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2009
Filed:
Jun. 09, 2003
Paolo Botti, Vessy, CH;
Matteo Villain, Rancho Palos Verde, CA (US);
Sonia Manganiello, Geneva, CH;
Hubert Gaertner, Archamps, FR;
Paolo Botti, Vessy, CH;
Matteo Villain, Rancho Palos Verde, CA (US);
Sonia Manganiello, Geneva, CH;
Hubert Gaertner, Archamps, FR;
Amylin Pharmaceuticals, Inc., San Diego, CA (US);
Abstract
The present invention provides methods of assembling oligopeptides or polypeptides in a native chemical ligation reaction that eliminates the formation of unwanted side products resulting from the presence of an unprotected acidic C-terminal oligopeptide thioester. An important aspect of the present invention is providing side chain protected acidic C-terminal oligopeptide thioesters. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins and improves the efficiency of native chemical ligation reactions, particularly where aspartyl or glutamyl peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.