Masato Ohbuchi

Title: Masato Ohbuchi: Innovator in Chimeric Non-Human Animal Research

Introduction

Masato Ohbuchi is a notable inventor from Japan, recognized for his contributions to the field of biotechnology. His work primarily focuses on the development of chimeric non-human animals that can carry human hepatocytes. This innovative approach has significant implications for drug metabolism research and therapeutic applications.

Latest Patents

Masato Ohbuchi holds a patent for a chimeric non-human animal carrying human hepatocytes. This invention provides a method for producing a chimeric non-human animal that lacks a drug-metabolizing system or has a suppressed drug-metabolizing system. The method involves transplanting human hepatocytes into a non-human animal characterized by being immunodeficient, having liver damage, and lacking the functions of an endogenous Cyp3a gene. This advancement is crucial for understanding how human cells can influence drug metabolism in a controlled environment.

Career Highlights

Throughout his career, Masato Ohbuchi has worked with prominent organizations such as Phoenixbio Co., Ltd. and Tottori University. His research has contributed to the advancement of biotechnology and has opened new avenues for medical research and drug development.

Collaborations

Masato Ohbuchi has collaborated with esteemed colleagues, including Mitsuo Oshimura and Yasuhiro Kazuki. These partnerships have enhanced the scope and impact of his research, fostering innovation in the field.

Conclusion

Masato Ohbuchi's work in developing chimeric non-human animals represents a significant advancement in biotechnology. His innovative research continues to influence the understanding of drug metabolism and its implications for human health.