The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2016
Filed:
Oct. 12, 2012
Mitsuo Oshimura, Tottori, JP;
Yasuhiro Kazuki, Tottori, JP;
Chise Mukaidani, Higashihiroshima, JP;
Takashi Shimada, Higashihiroshima, JP;
Masakazu Kakuni, Higashihiroshima, JP;
Satoko Hamamura, Higashihiroshima, JP;
Hidetaka Kamimura, Chuo-ku, JP;
Akio Kawamura, Chuo-ku, JP;
Naoyuki Nakada, Chuo-ku, JP;
Masato Ohbuchi, Chuo-ku, JP;
Kota Kato, Chuo-ku, JP;
Mitsuo Oshimura, Tottori, JP;
Yasuhiro Kazuki, Tottori, JP;
Chise Mukaidani, Higashihiroshima, JP;
Takashi Shimada, Higashihiroshima, JP;
Masakazu Kakuni, Higashihiroshima, JP;
Satoko Hamamura, Higashihiroshima, JP;
Hidetaka Kamimura, Chuo-ku, JP;
Akio Kawamura, Chuo-ku, JP;
Naoyuki Nakada, Chuo-ku, JP;
Masato Ohbuchi, Chuo-ku, JP;
Kota Kato, Chuo-ku, JP;
PHOENIXBIO CO., LTD., Higashihiroshima-shi, JP;
NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, Tottori-shi, JP;
Abstract
A chimeric non-human animal having an in vivo human hepatocyte population, wherein the effects of non-human animal cells on drug metabolism are suppressed or deleted is provided. A method for producing a chimeric non-human animal that lacks a drug-metabolizing system or has a suppressed drug-metabolizing system and is provided with a drug-metabolizing system driven by human hepatocytes, is provided. The method comprises transplanting human hepatocytes into a non-human animal characterized by (i) being immunodeficient, (ii) having liver damage, and (iii) lacking the functions of an endogenous Cyp3a gene.