Location History:
- Tsukuba, JP (2004 - 2006)
- Chuo-ku, JP (2009)
- Tokyo, JP (2012)
Company Filing History:
3 out of 416 
1 out of 329 Years Active: 2004-2012
Title: Masanao Sanagi: Innovator in Therapeutic Compounds
Introduction
Masanao Sanagi is a notable inventor based in Tsukuba, Japan, recognized for his contributions to the field of medicinal chemistry. He holds a total of four patents, focusing on innovative compounds that target diseases associated with the calcium sensing receptor (CaSR), particularly hyperparathyroidism.
Latest Patents
One of his latest patents is for a piperidine derivative or salt thereof. This compound is designed to treat diseases in which CaSR participates, especially hyperparathyroidism. The novel piperidine derivative is characterized by a substitution at either the 3-position or the 4-position with an aminomethyl group, which is further substituted with an arylalkyl group. The other position is substituted with aryl or heteroaryl groups. This compound exhibits excellent CaSR agonistic regulatory action and selectivity with a CYP2D6 inhibitory action, which may lead to drug interactions. Therefore, this piperidine derivative is a promising therapeutic agent for conditions like hyperparathyroidism, renal osteodystrophy, and hypercalcemia.
Another significant patent is for a pyrrolidine derivative or salt thereof. This compound also aims to treat diseases related to CaSR, particularly hyperparathyroidism. The novel pyrrolidine derivatives possess an aminomethyl group substituted with an arylalkyl group or similar structures. These compounds demonstrate excellent CaSR agonistic regulatory activity and selectivity with CYP2D6 inhibitory activity, making them valuable therapeutic agents for diseases associated with CaSR.
Career Highlights
Masanao Sanagi has worked with prominent companies in the pharmaceutical industry, including Astellas Pharma GmbH and Yamanouchi Pharmaceutical Company Ltd. His work in these organizations has contributed significantly to the development of innovative therapeutic solutions.
Collaborations
Some of his notable coworkers include Shunichiro Hachiya and Makoto Oku, who have collaborated with him on various projects in the field of medicinal chemistry.
Conclusion
Masanao Sanagi's innovative work in developing piperidine and pyrrolidine derivatives showcases his commitment to advancing therapeutic options for diseases related to the calcium sensing receptor. His contributions are vital in the ongoing quest for effective treatments in this area.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.