The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2012
Filed:
Nov. 14, 2007
Shunichiro Hachiya, Tokyo, JP;
Kazuhiro Ikegai, Tokyo, JP;
Ryotaro Ibuka, Tokyo, JP;
Taisuke Takahashi, Tokyo, JP;
Makoto Oku, Tokyo, JP;
Ryushi Seo, Tokyo, JP;
Yoh Terada, Tokyo, JP;
Masanao Sanagi, Tokyo, JP;
Shunichiro Hachiya, Tokyo, JP;
Kazuhiro Ikegai, Tokyo, JP;
Ryotaro Ibuka, Tokyo, JP;
Taisuke Takahashi, Tokyo, JP;
Makoto Oku, Tokyo, JP;
Ryushi Seo, Tokyo, JP;
Yoh Terada, Tokyo, JP;
Masanao Sanagi, Tokyo, JP;
Astellas Pharma, Inc., Tokyo, JP;
Abstract
To provide a compound which can be used for treating diseases in which a calcium sensing receptor (CaSR) participates, particularly hyperparathyroidism. It was found that a novel piperidine derivative which is characterized in that one of a 3-position and a 4-position is substituted with an aminomethyl group substituted with an arylalkyl group or the like and the other position is substituted with aryl, heteroaryl or the like, or a salt thereof, has an excellent CaSR agonistic regulatory action, and also has excellent selectivity with a CYP2D6 inhibitory action having a possibility of causing drug interaction. Based on the above, this novel piperidine derivative is useful as a therapeutic agent for diseases in which CaSR participates (hyperparathyroidism, renal osteodystrophy, hypercalcemia, and the like).