Martin Bard

Title: Martin Bard: Innovator in Sterol Biosynthesis

Introduction

Martin Bard is a notable inventor based in Carmel, IN (US), recognized for his contributions to the field of sterol biosynthesis. With a total of 4 patents to his name, Bard has made significant strides in understanding and manipulating sterol methyltransferase and related processes.

Latest Patents

One of Bard's latest patents involves DNA encoding sterol methyltransferase. This invention provides an isolated and purified nucleic acid molecule that encodes a sterol methyltransferase (ERG6). The invention also includes a strain or isolate that exhibits reduced levels of sterol methyltransferase due to the disruption of at least one sterol methyltransferase gene. These preferred isolates demonstrate increased susceptibility to various sterol synthesis and metabolic inhibitors compared to wild-type isolates. Additionally, Bard has developed methods to identify sterol methyltransferase inhibitors and to screen for antifungals or metabolic inhibitors that typically do not permeate fungal cells.

Another significant patent is the Sterol .DELTA.14 reductase screen. This binary assay identifies agents that inhibit sterol .DELTA.14 reductase, which is crucial in ergosterol biosynthesis. The primary screen assesses sterol .DELTA.14 reductase inhibition by adding a test sample to cultures of Neurospora crassa with specific erg mutations. Positive samples are identified based on growth inhibition patterns. The secondary screen further validates these samples using Saccharomyces cerevisiae strains, ensuring a highly sensitive and specific assay for detecting sterol .DELTA.14 reductase inhibitors.

Career Highlights

Throughout his career, Martin Bard has worked with prominent organizations, including American Cyanamid Company and Advanced Research & Technology Institute. His work has significantly impacted the understanding of sterol biosynthesis and its applications in various fields.

Collaborations

Bard has collaborated with notable colleagues, including Donald R. Kirsch and Margaret H. Lai, contributing to advancements in his research and patent developments.

Conclusion

Martin Bard's innovative work in sterol biosynthesis and his contributions through multiple patents highlight his role as a significant inventor in the field. His research continues to influence the understanding of sterol metabolism and its implications in various applications.