The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2001
Filed:
Mar. 13, 1998
Applicant:
Inventor:
Martin Bard, Carmel, IN (US);
Assignee:
Advanced Research and Technology Institute, Inc., Indianapolis, IN (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/48 ; C12N 1/14 ; C07H 2/104 ;
U.S. Cl.
CPC ...
C12Q 1/48 ; C12N 1/14 ; C07H 2/104 ;
Abstract
The invention provides an isolated and purified nucleic acid molecule encoding a,sterol methyltransferase (ERG6). Also provided is a,strain or isolate that has reduced levels of sterol methyltransferase as a result of the disruption of at least one sterol methyltransferase gene. Preferred isolates are more susceptible to a number of sterol synthesis and metabolic inhibitors relative to wild type isolates. Further provided are methods to identify sterol methyltransferase inhibitors and methods to screen for antifungals or metabolic inhibitors which are not normally permeable to the fungal cell.