Company Filing History:
Years Active: 2006-2012
Title: The Innovative Work of Marnie L. MacDonald in Protein-Fragment Complementation Assays
Introduction
Marnie L. MacDonald, an accomplished inventor based in Pleasanton, CA, has made significant contributions to the field of biotechnology through her innovative work. With a total of six patents to her name, her latest inventions focus on enhancing protein fragment complementation assays, which have vital applications in drug discovery and biological research.
Latest Patents
One of her most recent patents is centered on "Fragments of fluorescent proteins for protein fragment complementation assays." This invention addresses the generation of mutant fragments of fluorescent proteins with tailored spectral characteristics. By fragmenting fluorescent proteins, MacDonald has developed methods that allow for the creation of mutants which possess improved spectral properties compared to their wild-type counterparts. Her work encompasses a variety of fluorescent proteins, including green fluorescent protein (GFP) and its variants, as well as red fluorescent proteins. These innovations pave the way for efficient drug discovery tools, with applications ranging from high-throughput screening to biosensors.
Another notable patent reflects her pursuit of advancing "Protein fragment complementation assays for high-throughput and high-content screening." This invention further refines the process of using interacting protein pairs in combination with PCA reporters, facilitating the identification of compounds that can activate or inhibit cellular pathways. By exploring diverse libraries of compounds, MacDonald’s methods promise to streamline the process of drug discovery, allowing researchers to test effects on biochemical pathways efficiently.
Career Highlights
Marnie L. MacDonald is a prominent figure at Odyssey Thera Inc., where she has harnessed her expertise to develop cutting-edge technology in the realm of protein assays. Her dedication to enhancing drug discovery methodologies has positioned her as a key inventor in biotechnological innovation.
Collaborations
Throughout her career, Marnie has collaborated with esteemed colleagues such as Stephen William Watson Michnick and Jane Lamerdin. These partnerships showcase her ability to work with talented individuals in the scientific community, driving forward the research and application of her groundbreaking inventions.
Conclusion
Marnie L. MacDonald's contributions to protein fragment complementation assays exemplify her innovative spirit and deep understanding of biotechnological applications. With her ongoing dedication to advancing drug discovery methodologies, she continues to inspire future innovations in the field of biotechnology. Her work not only impacts research institutions but also holds great promise for the pharmaceutical industry, ushering in a new era of precision medicine and targeted therapeutics.