Company Filing History:
Years Active: 2022-2025
Title: **Marleen Eveline Weerdenburg: Innovator in Bioconjugate Production**
Introduction
Marleen Eveline Weerdenburg, an accomplished inventor based in Uithoorn, Netherlands, has made significant contributions to the field of bioconjugate production. With a total of four patents to her name, Weerdenburg is recognized for her innovative approaches and dedication to advancing pharmaceutical technology.
Latest Patents
Among her notable inventions, one of Weerdenburg's latest patents focuses on the production of O18 bioconjugates. This invention pertains to host cells designed for producing a bioconjugate of an O18 antigen polysaccharide conjugated to a carrier protein. These host cells are characterized by modified Wzy O-antigen polymerases, which display specific amino acid substitutions that enhance the yield and glycosylation patterns of the O18 bioconjugates produced. Furthermore, this patent also discusses methods utilizing these host cells to generate bioconjugate compositions, including multivalent adaptations featuring additional O antigen polysaccharide-serotypes.
Another recent patent by Weerdenburg describes polypeptides comprising a FimH lectin domain, which includes an amino acid mutation leading to a low-affinity conformation for mannose. This invention outlines pharmaceutical compositions that contain such polypeptides and introduces methods for stimulating an immune response in subjects by administering these polypeptides.
Career Highlights
Marleen Weerdenburg is currently employed at Janssen Pharmaceuticals, Inc., where her expertise and innovations are shaping the future of pharmaceutical solutions. Her inventive work not only propels advancements in medical science but also reflects her commitment to enhancing therapeutic strategies.
Collaborations
Throughout her career, Weerdenburg has collaborated with talented professionals, including her coworkers Jeroen Geurtsen and Jan Grijpstra. These collaborations have allowed her to blend expertise and drive impactful research in the pharmaceutical industry.
Conclusion
With a robust portfolio of patents and a dedicated career at Janssen Pharmaceuticals, Marleen Eveline Weerdenburg stands as an influential figure in bioconjugate development. Her innovative contributions continue to push the boundaries of pharmaceutical science, promising better healthcare solutions for many.