The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2022
Filed:
Jan. 15, 2021
Applicant:
Janssen Pharmaceuticals, Inc., Titusville, NJ (US);
Inventors:
Jan Grijpstra, Beesd, NL;
Marleen Eveline Weerdenburg, Uithoorn, NL;
Jeroen Geurtsen, Vleuten, NL;
Cristhina Kellen Fae, Oegstgeest, NL;
Jakob Louris Feitsma, Utrecht, NL;
Assignee:
Janssen Pharmaceuticals, Inc., Titusville, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/102 (2006.01); A61K 39/02 (2006.01); C07K 14/195 (2006.01); A61K 39/108 (2006.01);
U.S. Cl.
CPC ...
C07K 14/195 (2013.01); A61K 39/025 (2013.01); A61K 39/0266 (2013.01);
Abstract
Polypeptides comprising a FimH lectin domain comprising an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.