Marla J Koster

Title: **Marla J Koster: Pioneering Advances in Bovine Health**

Introduction

Marla J Koster is an accomplished inventor based in Cutchogue, NY, with a significant impact on veterinary science through her innovative research. With four patents to her name, she has played a crucial role in developing antiviral treatments for cattle, focusing on the challenges posed by foot-and-mouth disease virus (FMDV).

Latest Patents

Koster's notable latest patents include her work on the antiviral activity of bovine type III interferon against foot-and-mouth disease virus. She identified and characterized a member of the bovine type III interferon family, boIFN-β3, showcasing its effectiveness against both FMDV and vesicular stomatitis virus when administered in bovine cells in vitro. Her research demonstrated that treatment with boIFN-β3 could effectively reduce the severity of FMD in cattle, and it also conferred full protection against aerosol challenges for at least seven days after administration.

Additionally, Koster has developed a recombinant live attenuated foot-and-mouth disease vaccine featuring mutations in the L protein coding region of FMDV. Through these mutations, she created a virus that displayed a mild attenuated phenotype and led to significant antibody responses in vaccinated swine and cattle. Remarkably, her vaccine candidates demonstrated robust protection against homologous virus challenges just two days post-vaccination.

Career Highlights

Throughout her career, Marla J Koster has focused on enhancing bovine health through innovative vaccine development and antiviral therapies. Her research has not only contributed to scientific understanding but also aims to fill crucial gaps in emergency vaccination preparations against viral outbreaks in livestock.

Collaborations

Working with notable scientists such as Marvin J Grubman and Teresa B De Los Santos, Koster has combined her expertise with that of her colleagues to advance research initiatives in veterinary virology. These collaborations have led to comprehensive studies that underline the importance of her inventions.

Conclusion

Marla J Koster's contributions to the field of veterinary health through her inventive spirit and dedication to research have laid the groundwork for effective treatment strategies against viral diseases in cattle. Her innovative work continues to pave the way for future advancements in bovine medication, significantly impacting agricultural practices and animal health.