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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8906384 B1

PDFFull Text
Date of Patent:
Dec. 09, 2014

Filed:

Dec. 22, 2010

Antiviral activity of bovine type iii interferon against foot-and-mouth disease virus

Applicants:

Teresa B. DE Los Santos, Miller Place, NY (US);

James J. Zhu, Niantic, CT (US);

Fayna Diaz-san Segundo, Ronkonkoma, NY (US);

Marvin J. Grubman, Southold, NY (US);

Marla J. Koster, Cutchogue, NY (US);

Inventors:

Teresa B. De Los Santos, Miller Place, NY (US);

James J. Zhu, Niantic, CT (US);

Fayna Diaz-San Segundo, Ronkonkoma, NY (US);

Marvin J. Grubman, Southold, NY (US);

Marla J. Koster, Cutchogue, NY (US);

Assignee:

The United States of America as represented by The Secretary of Agriculture, Washington, CO (US);

Attorneys:

John D. Fado

Evelyn M. Rabin

Primary Examiner:

Shanon A Foley

Int. Cl.
CPC ...
A61K 39/12 (2006.01); C12N 15/63 (2006.01); A61P 31/12 (2006.01); C07H 21/04 (2006.01); A61K 31/7088 (2006.01); C07K 14/555 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/555 (2013.01); A61K 38/00 (2013.01);
Abstract

A member of the bovine type III IFN family, boIFN-λ3, was identified and characterized. We expressed boIFN-λ3 using a recombinant replication defective human adenovirus type 5 (Ad5) and demonstrated antiviral activity against foot-and-mouth disease virus (FMDV) and vesicular stomatitis virus (VSV) in bovine cells in vitro. Cattle were inoculated with Ad5-boIFN-λ3 followed by intradermolingual or aerosol FMDV challenge. Results demonstrated that the type III IFN family is conserved in bovines and that treatment of cattle with boIFN-λ3 alone or in combination with IFN-α is able to confer delayed and reduced severity of FMD. Furthermore inoculation with Ad5-boIFN-λ3 alone conferred full protection against aerosol challenge for at least 7 days after administration suggesting that type III IFN used in combination with FMD vaccines could fill one of the current gaps in emergency vaccination against FMDV.

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