Mark W Appleby

Title: The Innovative Contributions of Mark W. Appleby in Cytokine Research

Introduction

Mark W. Appleby, an inventive mind based in Shoreline, WA, has made significant strides in the field of immunology through his groundbreaking patents. With two patents to his name, Appleby continues to influence the scientific community with his work focused on the modulation of cytokine levels and the immune system.

Latest Patents

Among his latest innovations, Appleby's work titled "Manipulation of cytokine levels using CD83 gene products" stands out. This invention encapsulates methods for modulating cytokine levels and GM-CSF levels using various components such as CD83 nucleic acids, CD83 polypeptides, and anti-CD83 antibodies. The patent also introduces mice engineered with a mutant CD83 gene and those with a transgenic CD83 gene, providing invaluable tools for exploring the role of CD83 in the immune response and for discovering compounds that can influence CD83 activity.

Career Highlights

Mark W. Appleby has dedicated his career to advancing scientific knowledge through innovative research at Celltech R&D Limited. His work in immunology, particularly regarding the immune system's regulation, has opened new avenues for therapeutic interventions.

Collaborations

Throughout his journey, Appleby has collaborated with notable colleagues such as Fred Ramsdell and Sean Proll. These partnerships reflect a shared commitment to pioneering research that aims to enhance our understanding and management of immune-related conditions.

Conclusion

In summary, Mark W. Appleby's contributions to the field of cytokine research through his patents have not only advanced scientific understanding but also hold promise for future therapeutic developments. His commitment to innovation and collaboration underscores the vital role of inventors in shaping the landscape of medical research.