Mark R Nicolls

Title: Mark R Nicolls: Innovator in Medical and Electrochemical Technologies

Introduction

Mark R Nicolls is a prominent inventor based in Palo Alto, CA, known for his significant contributions to medical and electrochemical technologies. He holds a total of 8 patents, showcasing his innovative spirit and dedication to advancing scientific knowledge.

Latest Patents

Among his latest patents is the "HIF-1 modulator paint formulation and uses thereof." This invention provides formulations and methods aimed at improving the clinical outcomes of solid organ transplants, particularly lung transplantation. The method involves a nanoparticle formulation containing an effective dose of an iron chelator active agent, such as deferoxamine, deferasirox, and deferiprone, suspended in a tissue-compatible carrier. This formulation is topically applied to the surface of tissues at the site of anastomosis, enhancing the transplant's success.

Another notable patent is the "Nanogrid electrochemical sensor for detection of biochemical species by electrochemical impedance spectroscopy." This invention improves electrochemical impedance spectroscopy assays by electrodepositing metallic nanoparticles onto the working electrode. The incorporation of these nanoparticles enhances assay sensitivity and facilitates easier cleaning of the working electrode between assays.

Career Highlights

Mark R Nicolls has worked with esteemed institutions, including Leland Stanford Junior University and the United States Government as represented by the Department of Veterans Affairs. His work in these organizations has allowed him to contribute to groundbreaking research and development in his fields of expertise.

Collaborations

Throughout his career, Nicolls has collaborated with notable colleagues, including Jayakumar Rajadas and Wen A Tian. These partnerships have further enriched his research and innovation efforts.

Conclusion

Mark R Nicolls exemplifies the spirit of innovation through his patents and contributions to medical and electrochemical technologies. His work continues to impact the fields of organ transplantation and biochemical detection, showcasing the importance of inventive minds in advancing science and technology.