The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2020
Filed:
Jan. 29, 2019
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
The United States Government As Represented BY the Department of Veterans Affairs, Washington, DC (US);
The Johns Hopkins University, Baltimore, MD (US);
Mark R. Nicolls, Palo Alto, CA (US);
Jayakumar Rajadas, Cupertino, CA (US);
Geoffrey C. Gurtner, Woodside, CA (US);
Xinguo Jiang, Palo Alto, CA (US);
Gundeep Dhillon, Stanford, CA (US);
Gregg L. Semenza, Reisterstown, MD (US);
The Board Of Trustees of The Leland Stanford Junior University, Stanford, CA (US);
The United States Government as Represented By The Department Of Veterans Affairs, Washington, DC (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. suspended in a carrier compatible with the tissue of interest, is topically applied to the surface of tissues at the site of anastomosis. The nanoparticles are comprised of the active agent and a pharmaceutically acceptable stabilizer.