Mark R Holl

Title: Innovations by Mark R. Holl: Pioneering Microfluidic Technologies

Introduction

Mark R. Holl, based in Seattle, WA, is an accomplished inventor with a remarkable portfolio of 18 patents. His innovative contributions primarily focus on microfluidic technologies, leading to advancements that have significant implications in liquid analysis and storage systems.

Latest Patents

One of Holl's latest inventions is a sophisticated liquid analysis cartridge designed for the efficient storage of particle-containing liquids. This groundbreaking apparatus includes a microfluidic convoluted flow channel featuring multiple particle capture regions, utilizing an isotropic spatially periodic channel structure. Notably, the device enables the resuspension of sedimented particles post-storage, enhancing its practicality for various applications. The microfluidic analysis cartridge also accommodates several analysis channels, which may employ optical, electrical, pressure-sensitive, or flow-sensitive detection methods. These channels are strategically connected to reagent inlets for the addition of diluents, indicators, or lysing agents.

The cartridge features a mixing channel situated between the reagent inlet and analysis region to facilitate the mixing and reaction of reagents. Moreover, it incorporates additional valves and pumps for improved flow management and can be designed as a self-contained disposable unit, complete with an integral waste storage container. Holl's invention further includes an innovative sheath flow assembly that consists of a sample channel flanked by sheath fluid channels that converge with it. The design is flexible, allowing for formation via molding, machining, or etching, with a preferred method of lamination.

Career Highlights

Holl's career is notably anchored at the University of Washington, where he has engaged in pioneering research and development in the field of microfluidics. His work has not only expanded the boundaries of liquid analysis technology but has also paved the way for new applications in medical diagnostics and various industries.

Collaborations

Throughout his career, Mark R. Holl has collaborated with notable colleagues such as Bernhard Hans Weigl and Floyd Edwards, who have contributed to his research initiatives and innovations. These partnerships have been essential in enhancing the scope and impact of his inventions.

Conclusion

Mark R. Holl's contributions to the field of microfluidics through his patents exemplify the spirit of innovation and problem-solving. With a keen focus on practical applications, his work continues to influence various scientific fields and industries, underscoring the importance of advancements in liquid analysis and storage technologies. Through his inventions, Holl is set to leave a lasting legacy in the realm of microfluidic systems.