This inventor holds 2 USPTO granted patents. Top assignee: University of California. Active years: 1995-1996.
Location History:
- Los Alamos, NM (US) (1995)
- Angier, NC (US) (1996)
Company Filing History:
Years Active: 1995-1996
Title: Mark L Hammond: Innovator in DNA Fragment Analysis
Introduction
Mark L Hammond is a distinguished inventor based in Los Alamos, NM (US). He has made significant contributions to the field of molecular biology, particularly in the analysis of DNA fragments. With a total of 2 patents, his work has advanced the methodologies used in genetic research and forensic applications.
Latest Patents
Hammond's latest patents include innovative methods for DNA fragment sizing and sorting by laser-induced fluorescence. This method utilizes high-speed detection systems, such as flow cytometry, to determine unique characteristics of DNA pieces from a sample. The process involves fragmenting the DNA at preselected sites to produce multiple DNA fragments. These fragments are treated with a dye that stains them stoichiometrically. The fluorescence emitted from the stained fragments is then analyzed to generate data related to the number of nucleotides in each fragment. The intensity of the fluorescence emissions is linearly correlated to the fragment length, providing a characterization of the DNA piece for forensic and research applications.
Another notable patent is the method for rapid base sequencing in DNA and RNA with two-base labeling. This technique employs fluorescent detection of single molecules at two wavelengths. Modified bases that accept fluorescent labels are used to replicate a single DNA or RNA strand for sequencing. The bases are sequentially cleaved from the replicated strand and excited with electromagnetic radiation, allowing for the detection of fluorescence from individual, tagged bases in the order of cleavage.
Career Highlights
Mark L Hammond is affiliated with the University of California, where he continues to contribute to research and innovation in molecular biology. His work has garnered attention for its potential applications in various scientific fields.
Collaborations
Hammond has collaborated with notable colleagues, including James H Jett and Richard A Keller, further enhancing the impact of his research through teamwork and shared expertise.
Conclusion
Mark L Hammond's innovative approaches to DNA analysis have positioned him as a key figure in the field of molecular biology. His patents reflect a commitment to advancing scientific knowledge and practical applications in genetics.