Mark G Hartell

Title: Mark G Hartell: Innovator in Therapeutic Drug Development

Introduction

Mark G Hartell is a notable inventor based in Laurel, MD (US). He has made significant contributions to the field of therapeutic drug development, particularly in the formulation of artemisinin compounds. With a total of 2 patents, his work focuses on improving the stability and bioavailability of these important drugs.

Latest Patents

Hartell's latest patents include innovative formulations of artemisinin that enhance its therapeutic potential. One of his key inventions is a stable form of artemisinin wherein artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably β-cyclodextrin. This complexed formulation effectively shields the peroxide portion of the artemisinin backbone from hydrolytic decomposition, rendering it stable in solution. The interaction between artelinic acid and cyclodextrin yields a 2:1 molecular species, while artesunic acid and cyclodextrin yield a 1:1 molecular species. This formulation is particularly effective for the treatment of malaria and remains stable in solution for extended periods.

Career Highlights

Mark G Hartell is currently associated with the US Government as Represented by the Secretary of the Army. His work in this capacity has allowed him to contribute to advancements in drug development that can have a significant impact on public health.

Collaborations

Throughout his career, Hartell has collaborated with esteemed colleagues such as John E VanHamont and Wilbur K Milhous. These collaborations have further enriched his research and development efforts in the field of therapeutic drugs.

Conclusion

Mark G Hartell's innovative work in the formulation of artemisinin compounds showcases his dedication to improving therapeutic drug development. His contributions are vital in the ongoing fight against malaria and highlight the importance of stability and bioavailability in drug formulations.