The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2006
Filed:
Apr. 25, 2005
Mark G. Hartell, Laurel, MD (US);
Apurba K. Bhattacharjee, Silver Spring, MD (US);
Rickey P. Hicks, Woodbridge, VA (US);
John E. Vanhamont, Fort Meade, MD (US);
Wilbur K. Milhous, Germantown, MD (US);
Mark G. Hartell, Laurel, MD (US);
Apurba K. Bhattacharjee, Silver Spring, MD (US);
Rickey P. Hicks, Woodbridge, VA (US);
John E. VanHamont, Fort Meade, MD (US);
Wilbur K. Milhous, Germantown, MD (US);
The United States of America as represented by the Secretary of the Army, Washington, DC (US);
Abstract
A stable form of artemisinin wherein an artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably, β-cyclodextrin. The complexed cyclodextrin artemisinin formulation shields the peroxide portion of the artemisinin backbone from hydrolytic decomposition rendering it stable in solution. Artelinic acid and cyclodextrin are placed into contact with one another to yield a 2:1 molecular species. Artesunic acid and cyclodextrin yield a 1:1 molecular species. The complexed cyclodextrin artemisinin formulation is effective for the treatment of malaria and is stable in solution for long periods of time.