Company Filing History:
Years Active: 2005-2016
Title: Marie-Paule Lefranc: Innovator in Neonatal Diagnosis and Monoclonal Antibody Production
Introduction
Marie-Paule Lefranc is a distinguished inventor based in Clapiers, France. She has made significant contributions to the fields of neonatal serological diagnosis and monoclonal antibody production. With a total of 2 patents, her work has advanced medical diagnostics and therapeutic applications.
Latest Patents
One of her latest patents is a method for neonatal serological diagnosis. This invention provides a method for determining the amino acid polymorphisms of the heavy gamma chain of immunoglobulins G through a proteomic approach. It effectively distinguishes between the immunoglobulins of the mother and those of the newborn in a blood sample obtained during the first months of the child's life. The invention also relates to the early diagnosis of vertically transmitted diseases in neonates and includes peptides distinctive of G3m and IGHG3 alleles, along with a kit comprising these peptides.
Another notable patent involves the use of recombinant baculovirus in the production of monoclonal antibodies. This invention utilizes recombinant baculovirus as an expression vector for producing immunoglobulins with insect cells. It features a first expression cassette coding for a portion of an immunoglobulin heavy chain, controlled by a baculovirus promoter, and a second expression cassette for a portion of an immunoglobulin light chain, also controlled by a different baculovirus promoter.
Career Highlights
Marie-Paule Lefranc has worked with prominent research institutions, including the Centre National de la Recherche Scientifique and the Institut National de la Recherche Agronomique. Her work in these organizations has contributed to her expertise and innovation in her field.
Collaborations
Throughout her career, she has collaborated with notable colleagues such as Martine Cerutti and Hassan Chaabihi. These collaborations have further enriched her research and development efforts.
Conclusion
Marie-Paule Lefranc's innovative work in neonatal diagnostics and monoclonal antibody production showcases her significant contributions to medical science. Her patents reflect her commitment to advancing healthcare solutions and improving patient outcomes.
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