Marianna Romito

Title: Marianna Romito: Innovator in Cell Therapy and Gene Modification

Introduction

Marianna Romito is a prominent inventor based in Freiburg, Germany. She has made significant contributions to the fields of cell therapy and HIV treatments. With a total of two patents to her name, her work focuses on developing innovative solutions for medical challenges.

Latest Patents

One of her latest patents is titled "Sequence specific reagents targeting CCR5 in primary hematopoietic cells." This invention pertains to the field of cell therapy and HIV treatments. It provides highly specific reagents for reducing or inactivating the expression of CCR5 in primate and human primary cells, especially in the form of TALE-nucleases. These reagents allow the production of safer primary hematopoietic cells that are made resistant to HIV, including stem cells or differentiated cells, for infusion into HIV patients.

Another notable patent is "Construct for epigenetic modification and its use in the silencing of genes." This patent describes a construct for epigenomic modification of genes composed of several components. These include a Krüppel-associated box zinc finger protein, a DNA region capable of binding to the target gene, and human and murine DNA methyltransferases. The construct serves as a designer epigenome modifier that can silence genes coding for proteins in leukocytes, thereby preventing the internalization of HIV viruses in immune cells.

Career Highlights

Marianna has worked at notable institutions, including Albert-Ludwigs-Universität Freiburg and Cellectis. Her research has significantly advanced the understanding and treatment of HIV, showcasing her dedication to improving patient outcomes through innovative therapies.

Collaborations

Throughout her career, Marianna has collaborated with esteemed colleagues, including Toni Cathomen and Claudio Mussolino. These partnerships have further enriched her research and contributed to the success of her inventions.

Conclusion

Marianna Romito stands out as a leading inventor in the realm of cell therapy and gene modification. Her innovative patents and collaborative efforts reflect her commitment to advancing medical science and improving the lives of patients affected by HIV.