The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 27, 2021
Filed:
Apr. 11, 2018
Albert-ludwigs-universitaet Freiburg, Freiburg, DE;
Toni Cathomen, Freiburg, DE;
Claudio Mussolino, Freiburg, DE;
Tatjana I. Cornu, Freiburg, DE;
Tafadzwa Mlambo, Freiburg, DE;
Sandra Nitsch, Freiburg, DE;
Jamal Alzubi, Freiburg, DE;
Marianna Romito, Freiburg, DE;
Albert-Ludwigs-Universitaet Freiburg, Freiburg, DE;
Abstract
Herein described is a construct for epigenomic modification of genes composed of: (a) a Krüppel-associated box zinc finger protein or homologous, (b) a DNA region capable of binding to the target gene or homologous, (c) a human DNA methyltransferase DNMT3A or homologous and (d) a murine DNA methyltransferase Dnmt3L or homologous, wherein components a), b), c) and d) are linked to each other either directly or via at least one linker. The construct is a designer epigenome modifier that can be used to silence genes coding for a protein in leukocytes that avoids the internalization of HI viruses in immune cells.