Mariana De Maillé

Title: Innovations by Mariana De Maillé

Introduction

Mariana De Maillé is a prominent inventor based in Thousand Oaks, CA (US). She has made significant contributions to the field of solid-state nuclear magnetic resonance (NMR) through her innovative methods. Her work focuses on enhancing the understanding of macromolecule-containing solid-state formulations.

Latest Patents

Mariana holds 1 patent for her invention titled "Method for conducting solid state NMR on macromolecule-containing solid state formulations." This patent discloses a method for conducting direct detection solid-state NMR on macromolecule-containing solid-state formulations. The method involves conducting a hydrogen spin-lattice relaxation time (T1) experiment at various temperatures to generate T1 values, converting these values to hydrogen spin-lattice relaxation rates (R), and plotting R versus temperature to create a relaxation rate curve. This curve can be analyzed to determine the molecular mobility of the macromolecule, the degree of aggregation, and the stability of the solid-state formulation.

Career Highlights

Mariana has established herself as a key figure in her field, working at Amgen Inc., a leading biotechnology company. Her expertise in solid-state NMR has positioned her as an important contributor to advancements in drug formulation and stability analysis.

Collaborations

Throughout her career, Mariana has collaborated with notable colleagues, including Marc A Caporini and Ron C Kelly. These collaborations have further enriched her research and contributed to the success of her innovative projects.

Conclusion

Mariana De Maillé's contributions to the field of solid-state NMR exemplify her dedication to innovation and research. Her patent and work at Amgen Inc. highlight her role in advancing scientific understanding and technology in the pharmaceutical industry.