The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2024
Filed:
Oct. 02, 2020
Amgen Inc., Thousand Oaks, CA (US);
Marc A. Caporini, Belmont, MA (US);
Ron C. Kelly, Thousand Oaks, CA (US);
Mariana De Maillé, Thousand Oaks, CA (US);
AMGEN INC., Thousand Oaks, CA (US);
Abstract
Disclosed herein is a method of conducting direct detectionH solid state NMR ('ssNMR') on a macromolecule-containing solid state formulation. The method includes conducting aH spin-lattice relaxation time (“T”) experiment on the solid state formulation at various temperatures to generate a Tvalue at each temperature, converting the Tvalues toH spin-lattice relaxation rate (“R”), and plotting Rversus temperature to generate a relaxation rate curve for the solid state formulation. The relaxation rate curve can be analyzed to determine the molecular mobility of the macromolecule in the solid state formulation, the degree of aggregation in the solid state formulation, and/or the stability of the solid state formulation.