Company Filing History:
Years Active: 2013-2016
Title: Maria DiMarchi: Innovator in Glucagon Peptide Research
Introduction
Maria DiMarchi is a prominent inventor based in Carmel, IN (US). She has made significant contributions to the field of biochemistry, particularly in the development of glucagon peptides. With a total of 6 patents to her name, her work has had a profound impact on therapeutic approaches for metabolic disorders.
Latest Patents
One of her latest patents focuses on glucagon/GLP-1 receptor co-agonists. These modified glucagon peptides exhibit enhanced potency at the glucagon receptor compared to native glucagon. Further modifications, such as forming lactam bridges or substituting the terminal carboxylic acid with an amide group, result in peptides that demonstrate glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high-potency glucagon analogs can be improved through pegylation, substitution of carboxy terminal amino acids, or the addition of specific carboxy terminal peptides.
Career Highlights
Throughout her career, Maria has worked with notable institutions, including Indiana University and MSD Italia S.r.l. Her research has been pivotal in advancing the understanding of glucagon peptides and their applications in medicine.
Collaborations
Maria has collaborated with esteemed colleagues such as Richard Dennis DiMarchi and Joseph Chabenne. Their combined expertise has furthered the development of innovative solutions in the field of peptide research.
Conclusion
Maria DiMarchi's contributions to glucagon peptide research highlight her role as a leading inventor in the field. Her innovative work continues to influence therapeutic strategies for metabolic disorders, showcasing the importance of her research in modern medicine.