The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2013
Filed:
Jun. 16, 2009
Richard D. Dimarchi, Carmel, IN (US);
David L. Smiley, Bloomington, IN (US);
Maria Dimarchi, Carmel, IN (US);
Joseph Chabenne, Fishers, IN (US);
Jonathan Day, Bloomington, IN (US);
Richard D. Dimarchi, Carmel, IN (US);
David L. Smiley, Bloomington, IN (US);
Maria Dimarchi, Carmel, IN (US);
Joseph Chabenne, Fishers, IN (US);
Jonathan Day, Bloomington, IN (US);
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Abstract
Modified glucagon peptides are disclosed having improved solubility and/or half-life while retaining glucagon agonist activity. The glycogen peptides have been modified by substitution of native amino acids with, and/or addition of, charged amino acids to the carboxy terminus of the peptide. The modified glucagon agonists can be further modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 23, or both to further enhance the solubility of the glucagon agonist analogs.