Location History:
- Havana, CU (2002)
- Habana, CU (2002 - 2005)
Company Filing History:
2 out of 15 
1 out of 2 Years Active: 2002-2005
Title: **Maria De Jesus Leal Angulo: A Pioneer in Biotechnology Innovations**
Introduction
Maria De Jesus Leal Angulo is an innovative inventor based in Habana, Cuba, who has made significant contributions to the field of biotechnology. With a total of three patents to her name, she has demonstrated a strong commitment to advancing medical science and enhancing vaccine development through her groundbreaking work.
Latest Patents
One of her latest patents is a **Monoclonal antibody to the stabilizer peptide of the P64K antigen of Neisseria meningitidis**. This invention revolves around the expression of proteins of viral origin in microorganisms, utilizing recombinant DNA technology to create fusion peptides. The process is designed to yield these heterologous proteins with high purity and commercially viable quantities, facilitating their use in vaccine preparations. The technology employs a recombinant plasmid that includes a stabilizing sequence derived from the first 47 amino acids of the P64K antigen, effectively optimizing the protein expression.
Another important patent is the **formulation of nucleic acid and acemannan**. This invention revolves around a formulation that combines a nucleic acid vaccine with an immunoenhancing amount of acemannan, thereby improving the immune response in hosts. The method outlined in this patent serves to enhance the host's immune reaction to the nucleic acid vaccine, presenting a significant advancement in vaccine efficacy.
Career Highlights
Maria has worked at notable institutions, including the **Centro de Ingeniería Genética y Biotecnología**, where she has deepened her expertise in genetic engineering and biotechnology. Her endeavors in these organizations highlight her dedication to scientific research and innovation.
Collaborations
In her journey, Maria has collaborated with esteemed individuals such as Julio Cesar Aguilar Rubido and Verena Lucila Muzio Gonzalez. These partnerships have contributed to the advancement of her research and the successful development of her patented inventions.
Conclusion
Maria De Jesus Leal Angulo is a testament to the impact of innovative thinking in biotechnology. Through her patents, she continues to pave the way for advancements in vaccine technology and medical treatments, reaffirming her role as a leading inventor in the field. Her dedication to enhancing healthcare through scientific research is commendable and serves as an inspiration to aspiring inventors around the world.