The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2002
Filed:
Jan. 06, 2000
Julio Cesar Aguilar Rubido, Havana, CU;
Verena Lucila Muzio Gonzalez, Havana, CU;
Maria de Jesus Leal Angulo, Havana, CU;
Gerardo Enrique Guillen Nieto, Havana, CU;
Eduardo Penton Arias, Havana, CU;
Gloria Veliz Rios, Havana, CU;
Dagmara Pichardo Diaz, Havana, CU;
Antonieta Herrera Buch, Havana, CU;
Enrique Iglesias Perez, Havana, CU;
Luis Javier Cruz Ricondo, Havana, CU;
Tania Carmenate Portilla, Havana, CU;
Cirse Mesa Pardillo, Havana, CU;
Maydel Hechavarria Gay, Havana, CU;
Maylin Diaz Martinez, Havana, CU;
Juan Joel Madrazo Piñol, Havana, CU;
Centro de Ingenieria Genetica y Biotechnologia, Havana, CU;
Abstract
The present invention is related to the field of medicine, particularly to the use of new adjuvant formulations with vaccine antigens. The technical objective pursued with this invention is, precisely, the development of formulations that are able to increase and/or modulate the immune response of the organism to vaccine antigens in the serum and the mucous lining. With this aim, a formulation was developed that contained as the main components the surface antigen of the hepatitis B virus and the acemannan in adequate proportions. As an extension of this result, formulations were developed in which a) HBsAg was used as the homologous or heterologous antigen carrier b) delivery systems of particulated antigens and c) soluble antigens, combined with the acemannan in specific proportions. The formulations of this invention are applicable in the pharmaceutical industry as vaccine formulations for human and veterinary use.