Margo R Monroe

Title: Margo R. Monroe: Inventor in Gene and Mitochondrial Genome Editing.

Introduction

Margo R. Monroe is an inventor associated with Harvard College in Boston, Massachusetts. Her patent work addresses methods for editing and regulating genetic material in eukaryotic cells, including DNA-guided approaches and mitochondrial genome technologies. The available information lists 2 patents.

Latest Patents

Monroe’s listed patents focus on targeted genetic editing and regulation.

- DNA-Guided Gene Editing and Regulation. This invention describes methods and compositions for altering a eukaryotic cell. It uses a guide DNA sequence complementary to a target nucleic acid sequence, together with an Ago enzyme or a nuclease-null Ago protein. The system is designed to edit or regulate the target sequence at a specific site.

- Mitochondrial Genome Editing and Regulation. This invention describes methods for altering mitochondrial DNA in a eukaryotic cell. It uses a mitochondria-specific adeno-associated virus to deliver nucleic acids encoding a CRISPR system, including Cas9 or a nuclease-inactive variant and a guide RNA. Within mitochondria, the system can cut, nick, or regulate a target mitochondrial nucleic acid.

Career Highlights

Monroe’s listed patent portfolio reflects work on genetic engineering systems that target both cellular and mitochondrial nucleic acids. Her association with Harvard College connects this research to an academic institution.

Collaborations

The provided information identifies Luhan Yang and George M. Church as Monroe’s coworkers. Their names are associated with her collaborative research context in genetic editing and regulation.

Conclusion

Margo R. Monroe’s two listed patents address DNA-guided gene regulation and mitochondrial genome editing, highlighting approaches for precisely modifying genetic material.