Marcello Maresca

Title: Marcello Maresca: Innovator in Genetic Engineering

Introduction

Marcello Maresca is a prominent inventor based in Cambridge, MA (US). He has made significant contributions to the field of genetic engineering, particularly through his innovative patent that focuses on nuclease-based techniques.

Latest Patents

Maresca holds a patent titled "Methods of nuclease-based genetic engineering." This invention relates to genetic techniques that employ the direct ligation of an external DNA fragment generated in situ by the same zinc finger nucleases (ZFNs) that target the genome. The method, known as ObLiGaRe, or obligated ligation-gated recombination, introduces a new approach to genetic engineering using custom-designed nucleases. It utilizes a strategy of site-specific gene insertion through the non-homologous end joining (NHEJ) pathway, maintaining the advantages and flexibility of custom-designed nucleases.

Career Highlights

Marcello Maresca is currently associated with Novartis AG, where he continues to advance his research in genetic engineering. His work has garnered attention for its potential applications in various fields, including medicine and biotechnology.

Collaborations

Maresca collaborates with Yi Yang, contributing to the development of innovative solutions in genetic engineering.

Conclusion

Marcello Maresca's contributions to genetic engineering through his patent and work at Novartis AG highlight his role as a key innovator in the field. His research continues to pave the way for advancements in genetic techniques.