Location History:
- Barcelona, ES (2019 - 2021)
- Boston, MA (US) (2018 - 2022)
Company Filing History:
Years Active: 2018-2024
Title: Inventor Marc Guell: Pioneering Advances in Genome Editing
Introduction
Marc Guell, an innovative inventor based in Barcelona, Spain, has made significant contributions to the field of genetic engineering. With a robust portfolio of 8 patents, Guell's work is at the forefront of transformative scientific advancements.
Latest Patents
Among his latest innovations are two groundbreaking patents: the first focuses on a method for multiplexed genome editing. This technique involves modulating some or all copies of a gene in a cell by introducing ribonucleic acid (RNA) sequences that are complementary to specific target nucleic acid sequences. This methodology ensures that the Cas protein, crucial for gene editing, is expressed and effectively binds to the target sequences.
Guell’s second patent revolves around genome engineering. It provides methods for altering target DNA in genetically modified cells that express a Cas9 enzyme. This approach involves creating a co-localization complex with a guide RNA that is complementary to the target DNA. The guide RNA directs the Cas9 enzyme to cleave the DNA at specific locations, allowing for the insertion of donor nucleic acid sequences and resulting in the production of altered DNA within the cell.
Career Highlights
Marc Guell is affiliated with Harvard College, where he contributes to pioneering research in genetic modification. His extensive expertise in molecular biology and genetics positions him among the leading inventors in this rapidly evolving field.
Collaborations
Guell collaborates with notable figures in the scientific community, including George M. Church, a renowned geneticist, and Luhan Yang, a significant contributor to the field. These partnerships enhance the advancement of research and contribute to innovative solutions in genetic engineering.
Conclusion
In summary, Marc Guell stands out as a prominent inventor in Barcelona, driving forward the potential of genome editing with his innovative patents. His contributions, alongside collaborations with esteemed colleagues, are shaping the future of genetic research and applications.