Company Filing History:
10 out of 3,370 
1 out of 7 Years Active: 1989-2009
Title: The Innovative Contributions of Marc A. Longino
Introduction
Marc A. Longino is a notable inventor based in Ann Arbor, Michigan, with a remarkable portfolio of 11 patents. His work primarily focuses on advancements in medical imaging technologies, particularly in the development of blood-pool carriers for lipophilic imaging agents.
Latest Patents
Among his latest patents, Longino has developed a blood-pool carrier for lipophilic imaging agents. This invention features a surface-modified lipoprotein-like oil-in-water emulsion that serves as a selective delivery vehicle for lipophilic imaging agents or their derivatives. The carrier remains in the bloodstream for several hours, exhibits minimal early hepatic sequestration, and is cleared from the blood within 24 hours. The mean diameter of the oil phase is less than 150 nm, which helps to minimize sequestration by the reticuloendothelial system. Additionally, the surface of the oil phase is modified with a polyethyl glycol-modified phospholipid to prevent normal interactions with hepatocyte receptor sites. In radiographic imaging, various synthetic or semi-synthetic polyhalogenated triglycerides and lipid-soluble derivatives of traditional water-soluble contrast agents can be incorporated into the lipophilic core of the emulsion particle.
Career Highlights
Longino has made significant contributions to the field of medical imaging through his innovative patents. He has worked with esteemed institutions such as the University of Michigan and The Board of Regents Acting for and on Behalf of the University of Michigan. His expertise in developing advanced imaging technologies has positioned him as a key figure in this area of research.
Collaborations
Throughout his career, Longino has collaborated with notable colleagues, including Raymond E. Counsell and Jamey Paul Weichert. These collaborations have further enhanced the impact of his work in the field of medical imaging.
Conclusion
Marc A. Longino's contributions to medical imaging through his innovative patents demonstrate his commitment to advancing healthcare technology. His work continues to influence the development of effective imaging solutions that improve patient outcomes.
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