Company Filing History:
5 out of 15,475 
1 out of 10 
1 out of 5,450 
Years Active: 2010-2024
Title: Innovations and Contributions of Manuel L Penichet
Introduction
Manuel L Penichet is a notable inventor based in Los Angeles, California. He has made significant contributions to the field of cancer research through his innovative work and patented inventions. With a total of five patents, Penichet has focused on developing compounds that exhibit anticancer activity.
Latest Patents
One of his latest patents involves pyrazole derivatives with anticancer activity. The inventors utilized a differential nuclear staining (DNS) assay to discover compounds with cytotoxic activity against the CEM cell line, which is known to be highly sensitive to various anti-cancer compounds. These compounds were synthesized based on a pyrazole backbone structure. Among the newly synthesized compounds, one notable compound identified is the SSK-3 compound, which has been tested on cancer cell lines. It was determined that SSK-3 induced apoptosis via phosphatidylserine membrane exposure and activation of caspase 3 in the CEM lymphoma cell line. Another significant patent focuses on unconjugated anti-TfR antibodies and compositions for the treatment of cancer. This patent discloses methods and compositions for treating cancer, particularly highlighting the in vivo efficacy of unconjugated anti-TfR antibodies, such as ch128.1.
Career Highlights
Throughout his career, Manuel L Penichet has worked with esteemed institutions, including the University of California and Quest Pharmatech, Inc. His work has been instrumental in advancing cancer treatment methodologies and understanding the mechanisms of anticancer compounds.
Collaborations
Penichet has collaborated with notable colleagues, including Gustavo Helguera and Jay Dela Cruz, contributing to the collective effort in cancer research and innovation.
Conclusion
Manuel L Penichet's contributions to cancer research through his innovative patents and collaborations highlight his commitment to advancing medical science. His work continues to impact the field positively, paving the way for future advancements in cancer treatment.