The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2014
Filed:
Feb. 14, 2012
Manuel L. Penichet, Los Angeles, CA (US);
Birgit C. Schultes, Arlington, MA (US);
Christopher F. Nicodemus, Charlestown, MA (US);
Tracy R. Daniels, Woodland Hills, CA (US);
Gustavo Helguera, Long Beach, CA (US);
Jose A. Rodriguez, Paramount, CA (US);
Manuel L. Penichet, Los Angeles, CA (US);
Birgit C. Schultes, Arlington, MA (US);
Christopher F. Nicodemus, Charlestown, MA (US);
Tracy R. Daniels, Woodland Hills, CA (US);
Gustavo Helguera, Long Beach, CA (US);
Jose A. Rodriguez, Paramount, CA (US);
Quest Pharma Tech Inc., Alberta, CA;
The Regents of the University of California, Oakland, CA (US);
Abstract
The present invention provides monoclonal IgE antibodies comprising Fc epsilon (ε) constant regions and variable regions comprising at least one antigen binding region specific for binding a single epitope of a circulating, tumor-associated antigen (TAA) that is not a cell surface antigen wherein the epitope of the targeted antigen is not highly repetitive or is a non-repetitive epitope. The IgE antibodies of the invention are useful in the treatment of cancer associated with the tumor antigen. In one embodiment the TAA is prostate-specific antigen (PSA).