Manuel Kaulich

Title: Manuel Kaulich: Innovator in Gene Editing Technologies

Introduction

Manuel Kaulich is a prominent inventor based in Frankfurt-am-Main, Germany. He has made significant contributions to the field of gene editing, holding a total of 3 patents. His work focuses on developing innovative methods for generating gene editing vectors and libraries, which are crucial for advancing genetic research and applications.

Latest Patents

One of his latest patents is titled "Method for generating a gene editing vector with fixed guide RNA pairs." This invention pertains to a novel method for creating a vector construct suitable for gene editing applications, which includes a fixed pair of predetermined expressible guide RNA (gRNA) sequences. The method allows for easy construction of such vectors and provides vector libraries for the expression of fixed pairs of gRNAs. These vectors can be used to cut out larger genomic DNA sequences or to introduce mutations in the genome without losing larger genomic sequences. This system offers many molecular genetic approaches for genome alteration.

Another significant patent is "Method for generating higher order genome editing libraries." This invention describes a novel method for generating highly diverse RNA-expressing vectors and vector libraries for targeted gene knockout, knockdown, and genome modification approaches. The method allows for the creation of higher-order libraries without the need for classical cloning technologies, which is particularly useful for libraries based on large vectors. The vectors and libraries generated are intended for RNA-assisted silencing technologies, such as RNA interference, and for targeted genome editing using the CRISPR/Cas system or similar RNA/DNA-encoded gene perturbation systems. The invention also provides kits comprising the materials necessary for performing these methods.

Career Highlights

Manuel Kaulich has worked at notable institutions, including Johann Wolfgang Goethe-Universität Frankfurt Am Main and Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus. His work at these organizations has allowed him to contribute significantly to the field of molecular genetics and gene editing.

Collaborations

Throughout his career, Manuel has collaborated with esteemed colleagues, including Martin Wegner and Ivan Dikic. These collaborations have further enriched his research and innovations in gene editing technologies.

Conclusion

Manuel Kaulich is a key figure in the field of gene editing, with a focus on developing advanced methods and technologies. His contributions are paving the way for future innovations in genetic research and applications.