The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 02, 2024

Filed:

Oct. 18, 2018
Applicant:

Chemotherapeutisches Forschungsinstitut Georg-speyer-haus, Frankfurt am Main, DE;

Inventors:

Winfried Wels, Frankfurt, DE;

Anja Waldmann, Offenbach, DE;

Congcong Zhang, Frankfurt, DE;

Manuel Kaulich, Frankfurt am Main, DE;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); C07K 16/24 (2006.01); C12N 5/0783 (2010.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); C07K 16/244 (2013.01); C07K 16/248 (2013.01); C12N 5/0646 (2013.01); C12N 15/11 (2013.01); C12N 15/1136 (2013.01); C07K 2317/76 (2013.01); C12N 2310/14 (2013.01); C12N 2310/20 (2017.05); C12N 2501/2312 (2013.01); C12N 2501/2315 (2013.01);
Abstract

The present invention pertains to methods and compounds useful in a therapy involving the administration of immune cells to a patient. The method of the invention involves the modification of cells of the immune system with agonists or antagonists of immune regulators such as Interleukin-10 (IL-10) or IL-6, in order to enhance and improve the immunological potential of the immune cells for therapy. Cells modified according to the method of the invention can be administered to a patient to support a treatment of proliferative diseases such as cancer or autoimmune disorders.


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