This inventor holds 2 USPTO granted patents. Top assignee: University of California. Active years: 2010.
Location History:
- San Diego, CA (US) (2010)
- La Jolla, CA (US) (2010)
Company Filing History:
Years Active: 2010
Title: Innovations in Immunotherapy: The Contributions of Malini Sen
Introduction
Malini Sen is a prominent inventor based in San Diego, CA. She has made significant contributions to the field of immunotherapy, particularly in the context of head and neck squamous cell carcinomas. With a total of 2 patents, her work focuses on the intricate mechanisms of cancer biology and potential therapeutic targets.
Latest Patents
One of her latest patents is titled "Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas." This research investigates the diverse receptor-ligand pairs of the Wnt and frizzled (Fzd) families, which play crucial roles during embryonic development. The study highlights that these receptors may be overexpressed in cancers arising from immature cells. The mRNA levels and expression levels of five Wnt genes (Wnt-1, 5a, 7a, 10b, 13) and two Fzd genes (Fzd-2, 5) were analyzed in ten head and neck squamous carcinoma cell lines (HNSCC). Additionally, anti-Wnt-1 antibodies were utilized to explore the Wnt/Fzd signaling pathway. The findings suggest that HNSCC cell lines overexpress one or more Wnt and Fzd genes, indicating that the proliferation and survival of a subset of HNSCC may depend on the Wnt/Fzd pathway. Therefore, the Wnt and Fzd receptors may serve as valuable targets for immunotherapy in this common cancer.
Career Highlights
Malini Sen is affiliated with the University of California, where she continues her research and innovation in cancer therapies. Her work has garnered attention for its potential impact on treatment strategies for head and neck cancers.
Collaborations
Some of her notable coworkers include Christina Wu and Chae-Seo Rhee, who contribute to her research endeavors and collaborative projects.
Conclusion
Malini Sen's innovative work in immunotherapy exemplifies the potential of targeting specific pathways in cancer treatment. Her contributions are paving the way for new therapeutic strategies that could significantly improve patient outcomes.