The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2010
Filed:
May. 01, 2002
Chae-seo Rhee, Seoul, KR;
Malini Sen, La Jolla, CA (US);
Christina Wu, San Diego, CA (US);
Lorenzo M. Leoni, San Diego, CA (US);
Maripat Corr, San Diego, CA (US);
Dennis A. Carson, San Diego, CA (US);
Chae-Seo Rhee, Seoul, KR;
Malini Sen, La Jolla, CA (US);
Christina Wu, San Diego, CA (US);
Lorenzo M. Leoni, San Diego, CA (US);
Maripat Corr, San Diego, CA (US);
Dennis A. Carson, San Diego, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
The diverse receptor-ligand pairs of the Wnt and frizzled (Fzd) families play important roles during embryonic development, and thus may be overexpressed in cancers that arise from immature cells. The mRNA levels and expression levels of 5 Wnt (Wnt-1, 5a, 7a, 10b, 13) and 2 Fzd (Fzd-2, 5) genes in 10 head and neck squamous carcinoma cell lines (HNSCC) were investigated. In addition, anti-Wnt-1 antibodies were used to study the Wnt/Fzd signalling pathway. These results indicate that HNSCC cell lines overexpress one or more Wnt and Fzd genes, and the growth and survival of a subset of HNSCC may depend on the Wnt/Fzd pathway. Therefore, The Wnt and Fzd receptors may be useful targets for immunotherapy of this common cancer.