Location History:
- Fuchu, JP (2014)
- Tokyo, JP (2015 - 2017)
Company Filing History:
Years Active: 2014-2017
Title: Makiko Yamashita: Innovator in Neurodegenerative Disease Research
Introduction
Makiko Yamashita is a prominent inventor based in Tokyo, Japan. She has made significant contributions to the field of neurodegenerative diseases through her innovative research and patented inventions. With a total of 3 patents, her work focuses on developing methods to better understand and treat conditions such as ALS and FTLD.
Latest Patents
One of her latest patents is a method for producing an insoluble aggregate of neurodegenerative-disease-related protein. The purpose of this invention is to develop a method for amplifying in vitro a large amount of a homogenous insoluble aggregate that mimics the aggregates formed in the brains of patients. This method involves introducing an insoluble fraction from the brain of a neurodegenerative disease patient into a cell culture, culturing the cells, and then separating the insoluble fraction. Additionally, the method may include steps to amplify the insoluble aggregate within the cultured cells.
Another significant patent is the TDP-43-storing cell model. This invention discloses a transformed cell model capable of forming a cytoplasmic inclusion body derived from TAR DNA-binding protein of 43 kDa (TDP-43). This protein is associated with neurodegenerative diseases such as FTLD and ALS. The transformed cell is characterized by the introduction of a promoter that functions in a host cell and a mutant TDP-43 gene.
Career Highlights
Makiko Yamashita is affiliated with the Tokyo Metropolitan Institute of Medical Science, where she conducts her research. Her work has garnered attention for its potential impact on understanding neurodegenerative diseases and developing therapeutic strategies.
Collaborations
She collaborates with notable colleagues, including Takashi Nonaka and Haruhiko Akiyama, who contribute to her research efforts in the field.
Conclusion
Makiko Yamashita's innovative work in neurodegenerative disease research highlights her role as a leading inventor in this critical area of study. Her patents reflect her commitment to advancing scientific knowledge and improving patient outcomes.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.