The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 08, 2015
Filed:
Dec. 04, 2013
Applicant:
Tokyo Metropolitan Institute of Medical Science, Tokyo, JP;
Inventors:
Takashi Nonaka, Tokyo, JP;
Tetsuaki Arai, Chiba, JP;
Haruhiko Akiyama, Tokyo, JP;
Masato Hasegawa, Tokyo, JP;
Makiko Yamashita, Tokyo, JP;
Assignee:
Tokyo Metropolitan Institute of Medical Science, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5058 (2013.01); C07K 14/4711 (2013.01); G01N 33/5014 (2013.01);
Abstract
Disclosed is a transformed cell (a cell model) which can form a cytoplasmic inclusion body derived from TAR DNA-binding protein of 43 kDa (TDP-43) that is found in the brain of a patient suffering from a neurodegenerative disease such as FTLD and ALS. The transformed cell is characterized by having, introduced therein, a promoter capable of functioning in a host cell and a mutant TDP-43 gene.