Company Filing History:
Years Active: 2016-2017
Title: Mainul Hoque: Innovator in mRNA Decay Research
Introduction
Mainul Hoque is a notable inventor based in North Arlington, NJ (US). He has made significant contributions to the field of molecular biology, particularly in the area of mRNA decay. With a total of 2 patents, his work focuses on innovative methods for treating various conditions related to nonsense-mediated decay (NMD).
Latest Patents
Mainul Hoque's latest patents include groundbreaking methods for inhibiting nonsense-mediated mRNA decay. One of his patents, titled "Inhibition of nonsense mediated mRNA decay by drugs that prevent hypusination of eukaryotic initiation factor 5A," provides methods for treating a NMD by administering an inhibitor of NMD and a nonsense suppressor. This approach decreases the degradation of NMD susceptible mRNA and blocks translation termination at misplaced nonsense codons. Another patent, "Method of inhibiting nonsense-mediated mRNA decay," outlines methods for treating a NMD by administering a composition comprising an eIF5A inhibitor compound. This compound is effective in preventing intracellular hypusination of eIF5A, thereby increasing gene expression of NMD-susceptible mRNA.
Career Highlights
Mainul Hoque is affiliated with Rutgers, The State University of New Jersey, where he continues to advance his research in the field. His work has garnered attention for its potential applications in treating genetic disorders and other health issues related to mRNA decay.
Collaborations
Some of his notable coworkers include Tsafi Pe'ery and Michael B Mathews, who have collaborated with him on various research projects.
Conclusion
Mainul Hoque's innovative research and patents in the field of mRNA decay highlight his significant contributions to molecular biology. His work not only advances scientific understanding but also opens new avenues for therapeutic interventions.