Mahboubeh Kheirabadi

Title: Mahboubeh Kheirabadi: Innovator in Macrocyclic Peptide Purification

Introduction

Mahboubeh Kheirabadi is a prominent inventor based in Cambridge, MA (US). She has made significant contributions to the field of peptide synthesis and purification, holding two patents that showcase her innovative approaches.

Latest Patents

Her latest patents include methods for the non-chromatographic purification of macrocyclic peptides. The first patent focuses on the synthesis and improved methods for purifying macrocyclic peptides produced by solid phase peptide synthesis. This method involves capping the synthesized peptide with an alkyne-functionalized or azide-functionalized compound prior to cleavage from the solid phase support. The second patent also addresses non-chromatographic purification, detailing compounds and methods for preparing purified macrocyclic peptides using 'catch-release' methods. This process includes several steps, such as reacting a free amino group of a resin-bound linear peptide with a functionalized cap, cleaving the peptide, and ultimately achieving macrocyclization.

Career Highlights

Mahboubeh Kheirabadi is currently employed at Bristol-Myers Squibb Company, where she continues to advance her research in peptide synthesis. Her work has been instrumental in developing more efficient methods for peptide purification, which can have significant implications in pharmaceutical applications.

Collaborations

Some of her notable coworkers include Gardner S. Creech and Martin D. Eastgate, who have collaborated with her on various projects related to peptide synthesis and purification.

Conclusion

Mahboubeh Kheirabadi's innovative work in the field of macrocyclic peptide purification highlights her expertise and dedication to advancing scientific research. Her contributions are paving the way for more efficient methods in peptide synthesis, which can greatly benefit the pharmaceutical industry.