The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2024
Filed:
Sep. 13, 2022
Applicant:
Bristol-myers Squibb Company, Princeton, NJ (US);
Inventors:
Gardner S. Creech, North Holland, NL;
Mahboubeh Kheirabadi, Cambridge, MA (US);
Martin D. Eastgate, Titusville, NJ (US);
David S. Nirschl, Yardley, PA (US);
Percy H Carter, Princeton, NJ (US);
Assignee:
Bristol-Myers Squibb Company, Princeton, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 309/73 (2006.01); C07C 309/07 (2006.01); C07C 309/75 (2006.01); C07C 309/77 (2006.01); C07D 225/02 (2006.01); C07D 225/08 (2006.01); C07K 1/04 (2006.01); C07K 1/107 (2006.01); C07K 7/64 (2006.01); C07K 17/08 (2006.01);
U.S. Cl.
CPC ...
C07K 7/64 (2013.01); C07C 309/07 (2013.01); C07C 309/73 (2013.01); C07C 309/75 (2013.01); C07D 225/08 (2013.01); C07K 1/042 (2013.01); C07K 1/1077 (2013.01); C07K 17/08 (2013.01);
Abstract
The disclosure is directed to the synthesis and improved methods for purifying macrocyclic peptides produced by solid phase peptide synthesis. The synthesized peptide is capped with an alkyne-functionalized or azide-functionalized compound of formula (I): prior to cleavage of the peptide from the solid phase support.