Company Filing History:
Years Active: 2022-2024
Title: David S. Nirschl: Innovator in Macrocyclic Peptide Purification
Introduction
David S. Nirschl is a notable inventor based in Yardley, PA (US), recognized for his contributions to the field of peptide synthesis and purification. With a total of two patents to his name, Nirschl has made significant advancements in the methods used for purifying macrocyclic peptides.
Latest Patents
Nirschl's latest patents focus on non-chromatographic purification techniques for macrocyclic peptides. The first patent, titled "Non-chromatographic purification of macrocyclic peptides by a resin catch and release," details a synthesis method that improves the purification of macrocyclic peptides produced by solid-phase peptide synthesis. This method involves capping the synthesized peptide with an alkyne-functionalized or azide-functionalized compound before cleavage from the solid-phase support. The second patent also titled "Non-chromatographic purification of macrocyclic peptides by a resin catch and release," describes compounds and methods for preparing purified macrocyclic peptides using 'catch-release' methods. This innovative approach includes several steps, such as reacting a free amino group of a resin-bound linear peptide with a functionalized cap, cleaving the peptide, and facilitating macrocyclization.
Career Highlights
David S. Nirschl is currently employed at Bristol-Myers Squibb Company, where he continues to develop and refine his innovative techniques in peptide synthesis. His work has contributed to the advancement of pharmaceutical research and development, particularly in the area of peptide-based therapeutics.
Collaborations
Nirschl collaborates with talented professionals in his field, including Gardner S. Creech and Mahboubeh Kheirabadi. These collaborations enhance the research and development efforts at Bristol-Myers Squibb Company.
Conclusion
David S. Nirschl's contributions to the field of macrocyclic peptide purification demonstrate his commitment to innovation and excellence in peptide synthesis. His patents reflect a significant advancement in the methodologies used in pharmaceutical research, showcasing his role as a key inventor in this specialized area.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.