Location History:
- Gaithersburg, MD (US) (2019)
- Boyds, MD (US) (2013 - 2023)
Company Filing History:
Years Active: 2013-2023
Title: Innovations of Madhusudan V Peshwa
Introduction
Madhusudan V Peshwa is a notable inventor based in Boyds, MD (US). He has made significant contributions to the field of genomic DNA modification and therapeutic cell engineering. With a total of seven patents to his name, his work is at the forefront of biotechnological advancements.
Latest Patents
Madhusudan's latest patents include innovative methods for modifying genomic DNA. These compositions and methods focus on the sequence modification of an endogenous genomic DNA region. One aspect of his work involves a method for site-specific sequence modification of a target genomic DNA region in cells. This process includes contacting the cells with an activating composition and transfecting them with a transfection composition that comprises donor DNA and a DNA digesting agent. The donor DNA contains a homologous region and a sequence modification region, allowing for specific modifications at the target genomic DNA region.
Another significant patent involves the engineering and delivery of therapeutic compositions of freshly isolated cells. This invention relates to the transient modification of immune system cells, such as PBMC, PBL, T (CD3+ and/or CD8+), and Natural Killer (NK) cells. The modified cells express a genetically engineered chimeric receptor, which can be therapeutically administered to patients. The methods developed ensure efficient delivery of mRNA coding for the chimeric receptor to unstimulated resting immune cells, promoting significant target cell killing.
Career Highlights
Madhusudan V Peshwa is currently associated with Maxcyte Inc., where he continues to innovate in the field of biotechnology. His work has garnered attention for its potential applications in therapeutic treatments and genetic engineering.
Collaborations
Madhusudan has collaborated with notable colleagues, including Linhong Li and Weili Wang, contributing to the advancement of their shared research goals.
Conclusion
Madhusudan V Peshwa's contributions to genomic DNA modification and therapeutic cell engineering highlight his role as a leading inventor in the biotechnology sector. His innovative patents and ongoing work at Maxcyte Inc. continue to push the boundaries of scientific research and application.